Evasion of the immune-mediated cytotoxicity is an all too common hallmark of cancer. A recent study revealed that cancer vaccination -through the establishment of tumor reactive CD8 + CTLs-drives the evolution of tumor cells toward an immune-resistant and stem-like phenotype and they identified the transcription factor Nanog as a pivotal player in this process. Tellingly, the suppression of Nanog expression via using Nanog siRNA renders tumour cells more sensitive to immune response and leads

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... reduction of tumour growth. Taken together, the results of these studies support the notion that inhibiting Nanog may have therapeutic implications with respect to immune-based cancer therapy.