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The Antiepileptic Potential of Nucleosides
Current Medicinal Chemistry
Despite newly developed antiepileptic drugs to suppress epileptic symptoms, approximately one third of patients remain drug refractory. Consequently, there is an urgent need to develop more effective therapeutic approaches to treat epilepsy. A great deal of evidence suggests that endogenous nucleosides, such as adenosine (Ado), guanosine (Guo), inosine (Ino) and uridine (Urd), participate in the regulation of pathomechanisms of epilepsy. Adenosine and its analogues, together with non-adenosinedoi:10.2174/1381612819666131119154505 pmid:24251559 fatcat:nuib7fvezzhibljrwltm67i6hy