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Arginase inhibition protects against hypoxia-induced pulmonary arterial hypertension
Molecular Medicine Reports
The present study aimed to determine the role of arginase (Arg) in pulmonary arterial hypertension (PAH). In vitro, human pulmonary artery smooth muscle cells (HPASMCs) were cultured under hypoxic conditions with, or without, the Arg inhibitor, S-(2-boronoethyl)-l-cysteine (BEC), for 48 h, following which the proliferation of the HPASMCs was determined using MTT and cell counting assays. For the in vivo investigation, 30 male rats were randomly divided into the following three groups (n=10 perdoi:10.3892/mmr.2015.3994 pmid:26126810 fatcat:ayvpnvxhrncttehtwule3rid5m