Chronic Renal Disease (CKD) is understood as a clinical syndrome characterized by the gradual and progressive reduction of excretory, endocrine and metabolic renal functions. Objective: To evaluate the quality of life in patients with CKD on hemodialysis. Methods: Exploratory, longitudinal study with analytical quantitative analysis. Data collected in the period from February to June 2015, at the Reference Nephrology Unit of the western region of Santa Catarina. The instrument used was the

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... ionnaire: KDQOL-SF ™ 1.3 (Kidney Disease Quality of Life -Short Form 1.3). Results: 42 patients participated, 52.38% were males and 57% of the total sample presented in adulthood. The "emotional performance" dimension obtained a higher mean score (92.06) followed by the "encouragement of dialysis staff" dimension (91.67); the "sexual function" dimension had a lower average score (23.81) followed by "general health" (39.40).Conclusion: It was observed that at the beginning of the Treatment the patients present physical and later emotional changes. It is up to health professionals and their families to deal with patients with CKD in hemodialysis treatment, to understand the same as singular, to recognize their real potentialities and fragilities, in order to trace care and plans directed to the real situation of the patient.