Despite the popularity of needle biopsy for obtaining tissue samples in several solid organs, its use in thoracic lesions has been very restricted in some hospitals. This study intended to investigate the CT-Guided transthoracic core needle biopsy specimens in Yazd Shahid Sadoughi hospital during 2001-2010. Methods: This is a retrospective cross-sectional study conducted on pathologic results of CT-Guided transthoracic core needle biopsy specimens in Shahid Sadoughi hospital from 2001-2010.

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... lts: In our study, 89 thoracic CNB were studied between2001-2010 from patients that referred to Sadoughi hospital who involved 53 males and 36 females. 78 biopsies were from lung and 11 biopsies from Mediastin. In a total of 89 biopsies 71 biopsies (78.9%) supplied appropriate material for histopathological diagnosis. Results were classified into one of the following four groups: positive or suspicious for malignancy(19.1%), benign specific(34.8%), benign non-specific(25.8%) and non-diagnostic(20.2%). Conclusion: Based on multivariate analysis there was no significant correlation between age ,sex ,size of lesion and pathology results, but there was a significant correlation between the location of thoracic lesion in lung and pathology results (p-value=0.024). Application of automated system for biopsy and fluoroscopy CT for guidance of needle biopsy can elevate adequacy of core needle biopsy in thoracic lesion.