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Proteogenomics: Integrating Next-Generation Sequencing and Mass Spectrometry to Characterize Human Proteomic Variation
2016
Annual Review of Analytical Chemistry
Mass spectrometry-based proteomics has emerged as the leading method for detection, quantification, and characterization of proteins. Nearly all proteomic workflows rely on proteomic databases to identify peptides and proteins, but these databases typically contain a generic set of proteins that lack variations unique to a given sample, precluding their detection. Fortunately, proteogenomics enables the detection of such proteomic variations and can be defined, broadly, as the use of nucleotide
doi:10.1146/annurev-anchem-071015-041722
pmid:27049631
pmcid:PMC4991544
fatcat:pebtnvfkenaktec4jxbdgs635i