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Short-read high-throughput DNA sequencing technologies provide new tools to answer biological questions. However, high cost and low throughput limit their widespread use, particularly in organisms with smaller genomes such as S. cerevisiae. Although ChIP-Seq in mammalian cell lines is replacing array-based ChIP-chip as the standard for transcription factor binding studies, ChIP-Seq in yeast is still underutilized compared to ChIP-chip. We developed a multiplex barcoding system that allowsdoi:10.1186/1471-2164-10-37 pmid:19159457 pmcid:PMC2656530 fatcat:4zyqx2xy2jbi7kfacxwqvnfxnm