Interferon-α-2a Is a Potent Inhibitor of Hormone Secretion by Cultured Human Pituitary Adenomas

Leo J. Hofland, Wouter W. de Herder, Marlijn Waaijers, Joke Zuijderwijk, Piet Uitterlinden, Peter M. van Koetsveld, Steven W. J. Lamberts
1999 Journal of Clinical Endocrinology and Metabolism  
Interferon-␣ (IFN␣) may exert direct inhibitory effects on cell proliferation and on the production of different peptide hormones. We investigated the effect of IFN␣ on hormone production by 15 GHsecreting pituitary adenomas, 4 clinically nonfunctioning or gonadotroph pituitary adenomas, and 4 prolactinomas in vitro. In the GHsecreting pituitary adenoma cultures, a short term (72-h) incubation with IFN␣ (50 -100 U/mL) significantly inhibited GH secretion in 3 of 7 cases and PRL secretion in 6
more » ... 7 cultures. During prolonged incubation (14 days) with IFN␣, GH and/or PRL secretion was significantly inhibited in 7 of 8 cultures (GH, 17-78% inhibition; PRL, 39 -88% inhibition). In the clinically nonfunctioning or gonadotroph cultures, incubation with IFN␣ resulted in inhibition of the secretion of gonadotropins and/or ␣-subunit in all cases (27-62%), whereas in the prolactinoma cultures PRL secretion was inhibited by IFN␣ in all cases (37-76%). The effect of IFN␣ was additive to the inhibitory
doi:10.1210/jcem.84.9.6005 pmid:10487708 fatcat:e4k5tk7yrjderpp3eqr4omvonq