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The effects of organic solvents on the folding pathway and associated thermodynamics of proteins: a microscopic view
2016
Scientific Reports
Protein folding is subject to the effects of solvation environment. A variety of organic solvents are used as additives for in vitro refolding of denatured proteins. Examination of the solvent effects on protein folding could be of fundamental importance to understand the molecular interactions in determining protein structure. This article investigated the folding of α-helix and β-hairpin structures in water and the solutions of two representative refolding additives (methanol (MeOH) and
doi:10.1038/srep19500
pmid:26775871
pmcid:PMC4726029
fatcat:mjimchlnofdwzjxhqmg2xo6bym