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Cancer, which is the most important health problem, develops the ability to resistant traditional medications this leads to increase efforts to develop new cancer medication protocols. In this review, the chemotherapy resistance could be due to several mechanisms. These mechanisms involve either inactivation by two important phases, phase I which involve oxidation, reduction and hydrolysis or phase II which involve conjugation wi, alteration of the target site which decrease either activationdoi:10.37506/ijfmt.v15i1.13512 fatcat:vol5nbnsnrbmbb5tkosw4ncwc4