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Diffusion basis spectrum imaging detects and distinguishes coexisting subclinical inflammation, demyelination and axonal injury in experimental autoimmune encephalomyelitis mice
2014
NMR in Biomedicine
Clinicopathological paradox has significantly hampered the effective assessment of the efficacy of therapeutic intervention of multiple sclerosis. The neuroimaging biomarkers of tissue injury could guide a more effective treatment by accurately reflecting the underlying subclinical pathologies. Diffusion tensor imaging-derived directional diffusivity and anisotropy indices have been applied to characterize white matter disorders. However, these biomarkers are sometimes confounded by complex
doi:10.1002/nbm.3129
pmid:24816651
pmcid:PMC4071074
fatcat:5tslqbdv3bdc5ki3skybjypmr4