THE USE OF THE THIOL-DISULFIDE HOMEOSTASIS AS AN INDICATOR OF OXIDATIVE STRESS IN PEDIATRIC ADENOID HYPERTROPHY PATIENTS

Kadir Ozdamar, Alper Sen, Ismail Koyuncu
2019 Sanamed  
To the best of our knowledge, no study has yet focused on the association between the adenoid hypertrophy (AH) and the thiol-disulphide balance. Objectives: The purpose of this study is to evaluate the relation between AH and the thiol-disulphide balance, which is used as a marker of oxidative stress (OS), by measuring its exchange using a novel technique. Study design: Non-randomized and prospective clinical study. Material and methods: The present study consisted of 25 patients who presented
more » ... ents who presented to the otolaryngology outpatient clinic of our hospital with AH. An ageand sex-matched control group was composed of 24 healthy children. The effect of AH on the thiol-disulphide balance in children was evaluated. We also evaluated the total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), ferric reducing/antioxidant power (FRAP), glutathione (GSH), lipid hydroperoxide (LOOH) and advanced oxidation protein products (AOPP) to assess the OS status of children. Results: The TOS was significantly higher in the AH group and the TAS was significantly higher in the control group (all p values < 0.05). The mean values of OSI, LOOH and AOPP were significantly higher in the AH group than the control group ( all p values < 0.05). Native thiol and total thiol levels were lower in the AH group than those of the control group (p < 0.05). Disulphide level and disulphide/native thiol and disulphide/total thiol ratios were higher in the AH group than that of the control group (all p values < 0.05). Conclusion: In conclusion, we observed decreased thiols with increased disulphide values in children with AH compared with the controls. Thiol/disulphide homeostasis can be used as an indicator of OS in children with AH. Uvod: Do sada nijedna studija se nije fokusirala na povezanosti adenoidne hipertrofije i tioldisulfidne homeostaze. Cilj: cilj na{e studije bio je da se proceni povezanost izme|u adenoidne hipertrofije i tioldisulfid-ne homeostaze, koja se koristi kao jedan od markera oksidativnog stresa (OS), tako {to smo merili njegovu raznemu koriste}i novel tehniku. Dizajn studije: nerandomizovana i prospektivna klini~ka studija.
doi:10.24125/sanamed.v14i1.292 fatcat:ilvfamu3uvgetey54hed57v34m