Kadir Ozdamar, Alper Sen, Ismail Koyuncu
2019 Sanamed  
To the best of our knowledge, no study has yet focused on the association between the adenoid hypertrophy (AH) and the thiol-disulphide balance. Objectives: The purpose of this study is to evaluate the relation between AH and the thiol-disulphide balance, which is used as a marker of oxidative stress (OS), by measuring its exchange using a novel technique. Study design: Non-randomized and prospective clinical study. Material and methods: The present study consisted of 25 patients who presented
more » ... ents who presented to the otolaryngology outpatient clinic of our hospital with AH. An ageand sex-matched control group was composed of 24 healthy children. The effect of AH on the thiol-disulphide balance in children was evaluated. We also evaluated the total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), ferric reducing/antioxidant power (FRAP), glutathione (GSH), lipid hydroperoxide (LOOH) and advanced oxidation protein products (AOPP) to assess the OS status of children. Results: The TOS was significantly higher in the AH group and the TAS was significantly higher in the control group (all p values < 0.05). The mean values of OSI, LOOH and AOPP were significantly higher in the AH group than the control group ( all p values < 0.05). Native thiol and total thiol levels were lower in the AH group than those of the control group (p < 0.05). Disulphide level and disulphide/native thiol and disulphide/total thiol ratios were higher in the AH group than that of the control group (all p values < 0.05). Conclusion: In conclusion, we observed decreased thiols with increased disulphide values in children with AH compared with the controls. Thiol/disulphide homeostasis can be used as an indicator of OS in children with AH. Uvod: Do sada nijedna studija se nije fokusirala na povezanosti adenoidne hipertrofije i tioldisulfidne homeostaze. Cilj: cilj na{e studije bio je da se proceni povezanost izme|u adenoidne hipertrofije i tioldisulfid-ne homeostaze, koja se koristi kao jedan od markera oksidativnog stresa (OS), tako {to smo merili njegovu raznemu koriste}i novel tehniku. Dizajn studije: nerandomizovana i prospektivna klini~ka studija.
doi:10.24125/sanamed.v14i1.292 fatcat:ilvfamu3uvgetey54hed57v34m