SYNTHESIS, STRUCTURAL CHARACTERISATION AND BIOLOGICAL EVALUATION OF NOVEL SERIES OF BENZIMIDAZOLE CLUBBED CHALCONE DERIVATIVES

SRAVANTHI AVUNOORI
2020 Journal of Bio Innovation  
Benzimidazoles are the fused bicyclic systems containing nitrogen as heteroatom possessing significant biological importance. Chalcones belonging to group of aromatic ketones are utilized as core molecules exhibiting potent pharmacological activities. By condensing o-amino phenols with chalcone alcohols in presence of ammonia, carbon tetrachloride and palladium afforded novel benzimidazole clubbed chalcones with efficient yield. 10 derivatives were prepared and structurally characterised by 1
more » ... MR, IR and mass spectroscopic methods. The synthesised compounds were evaluated for antibacterial activity and produced satisfactory results.
doi:10.46344/jbino.2020.v09i04.04 fatcat:6nvylcxpjvb6xpn344ewdyofda