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The Role of Protein Interactions in Mediating Essentiality and Synthetic Lethality
2013
PLoS ONE
Genes are characterized as essential if their knockout is associated with a lethal phenotype, and these "essential genes" play a central role in biological function. In addition, some genes are only essential when deleted in pairs, a phenomenon known as synthetic lethality. Here we consider genes displaying synthetic lethality as "essential pairs" of genes, and analyze the properties of yeast essential genes and synthetic lethal pairs together. As gene duplication initially produces an
doi:10.1371/journal.pone.0062866
pmid:23638160
pmcid:PMC3639263
fatcat:y23g4s7cxnbzfi5ligdgfwc2fu