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A thermodynamic model of protein structure evolution explains empirical amino acid substitution matrices
2021
Protein Science
Proteins evolve under a myriad of biophysical selection pressures that collectively control the patterns of amino acid substitutions. These evolutionary pressures are sufficiently consistent over time and across protein families to produce substitution patterns, summarized in global amino acid substitution matrices such as BLOSUM, JTT, WAG, and LG, which can be used to successfully detect homologs, infer phylogenies, and reconstruct ancestral sequences. Although the factors that govern the
doi:10.1002/pro.4155
pmid:34218472
pmcid:PMC8442976
fatcat:626efhku35a23hlwd6yinnyzxi