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Metabolism of sphingomyelin in cultured skin fibroblasts from patients with different types of Niemann-Pick disease
1986
Tohoku journal of experimental medicine
The metabolism of [choline-methyl-14C] sphingomyelin in cultured skin fibroblasts from patients with different types of Niemann-Pick disease was measured 1 and 3 days after uptake from the media. The cell lines obtained from type A disease had more than 95° unhydrolyzed sphingomyelin in situ on day 3 while two cell lines obtained from type B had 36.3° and 43.3° unhydrolyzed sphingomyelin on day 3. The cell line derived from one patient with the transitory type disease had 48.1% unhydrolyzed
doi:10.1620/tjem.148.365
pmid:3738903
fatcat:d3sovn262ba37k7u3sqhmz6wkq