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Development and Optimization of a Silica Column-Based Extraction Protocol for Ancient DNA
2022
Genes
Rapid and cost-effective retrieval of endogenous DNA from ancient specimens remains a limiting factor in palaeogenomic research. Many methods have been developed to increase ancient DNA yield, but modifications to existing protocols are often based on personal experience rather than systematic testing. Here, we present a new silica column-based extraction protocol, where optimizations were tested in controlled experiments. Using relatively well-preserved permafrost samples, we tested the
doi:10.3390/genes13040687
pmid:35456493
pmcid:PMC9032354
fatcat:ud2265r5jfgf3jojsjwolfwfg4