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Adrenaline Activates Human Platelets But Does Not Cause Primary Aggregation If Thrombin Generation Is Inhibited By Hirudin
Thrombosis and Haemostasis
Adrenaline(ADR) affects human platelets(PLAT) by binding to a receptors,inhibiting adenylate cyclase and translocating Ca2+ across the plasma membrane. In citrated PLAT-rich plasma(CIT-PRP), ADR induces primary aggregation(1stAGG), which may be followed by 2ndAGG due to the activation of the arachidonate(AA) pathway and the release(REL) of ADP. ADR acts synergistically with other aggregating agents. In contrast, ADR does not aggregate suspensions of washed human PLAT(SWHP) and hirudin(HIR)-PRP.doi:10.1055/s-0038-1652238 fatcat:a3jaqskrf5flhjtt4zjguig5m4