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Links between growth hormone and aging
2013
Endokrynologia Polska
Studies in mutant, gene knock-out and transgenic mice have demonstrated that growth hormone (GH) signalling has a major impact on ageing and longevity. Growth hormone-resistant and GH-deficient animals live much longer than their normal siblings, while transgenic mice overexpressing GH are short lived. Actions of GH in juvenile animals appear to be particularly important for life extension and responsible for various phenotypic characteristics of long-lived hypopituitary mutants. Available
pmid:23450447
pmcid:PMC3647466
fatcat:4aw7uhpkgvhvvlebj5bjwevy4m