Insights and controversies into the role of the key apicomplexan invasion ligand, Apical Membrane Antigen 1

Katherine L. Harvey, Alan Yap, Paul R. Gilson, Alan F. Cowman, Brendan S. Crabb
2014 International Journal of Parasitology  
Apicomplexan parasites are obligate intracellular pathogens that cause a host of human and animal diseases. These parasites have developed a universal mechanism of invasion involving formation of a 'moving junction' that provides a stable anchoring point through which the parasite invades host cells. The composition of the moving junction, particularly the presence of the protein Apical Membrane Antigen 1 (AMA1), has recently been the subject of some controversy. In this commentary we review
more » ... dings that led to the current model of the moving junction complex and dissect the major conflicts to determine whether a substantial reassessment of the role of AMA1 is justified.
doi:10.1016/j.ijpara.2014.08.001 pmid:25157917 fatcat:zwhd6jhrvnexzl42avvkxkmbyu