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Weight Loss Induced by Bariatric Surgery Restricts Hepatic GDF15 Expression
2018
Journal of Obesity
Introduction. Obesity and related nonalcoholic fatty liver disease (NAFLD) are an emerging health care issue that imposes substantial morbidity to individuals. Growth and differentiation factor 15 (GDF15) limits food uptake, body weight, and energy balance by modulation of GDNF-family receptor α-like (GFRAL) signalling in the hindbrain. However, the regulation of GDF15 expression in obesity and NAFLD is incompletely understood. We sought to define the impact of weight loss achieved by
doi:10.1155/2018/7108075
fatcat:cirfq2mssvd2plin3vsxixcrge