Anti-inflammatory Effect of cream and ointment from 2,5- bis- (4-Nitrobenzilidine) cyclopentanoneagainst Edema in Mice Induced by Formalin

Paulina Maya Octasari, Fransiska Ayuningtyas
2016 JPSCR Journal of Pharmaceutical Science and Clinical Research  
Cream<span style="text-decoration: line-through;">s </span>and ointment<span style="text-decoration: line-through;">s</span> are topical dosage forms used in the manufacture of drugs. Topical anti-inflammatory drug is a solution to problems of gastrointestinal side effects caused by taking nonsteroidal anti-inflammatory drug orally. The compound 2,5-bis (4-nitrobenzilidine) cyclopentanone is an analog of curcumin which has better anti-inflammatory activity than curcumin. This study aimed to
more » ... rmine the antiinflammatory effect of cream and ointment from 2,5-bis (4-nitrobenzilidine) cyclopentanoneagainst edema in mice induced by formalin. This research were experimental randomized complete design using a single factor. Twenty mice were divided into 4 groups: group I were given a cream base, the group II were given ointment base, group III were given cream compound 0.25% and group IV were given ointment compound 0.25%. The data were processed into AUC values and the percentage of anti-inflammatory effectwere calculated. Results were analyzed using ANOVA and T-test statistics. The results showed that between the dosage form had statistically difference of anti-inflammatory effect (p&lt;0.05). The ointmentshowed a greater value of antiinflammatory activity rather than cream.
doi:10.20961/jpscr.v1i2.1942 fatcat:7uku5reg6rhqbc5rmdittkrf6y