Evaluation of the Anti-Diabetic Activity of Sophora Interrupta: Pharmacological Screening Against Streptozotocin-Induced Diabetic Rats
International Journal of Current Research and Review
Diabetes Mellitus (DM) is a highly prevalent metabolic disorder characterized by chronic hyperglycaemia. Though multiple conventional therapies are available these therapies are reported to have side effects. Aim: To evaluation of the anti-diabetic activity of Sophora interrupta by using the streptozotocin-induced diabetic rat model. Plants are potential sources of phytoconstituents with varied pharmacological activities. Methodology: The leaves and the stem bark of Sophora interrupta(SI) were
... ollected and initial results of the phytochemical screening revealed that all the bark and leaf extract of the plant showed the presence of flavonoids, Saponins, steroids, alkaloids, tannins, phenolic compounds, triterpenoids and carbohydrates. Results: The results of acute toxicity studies demonstrated that animals did not display any drug-related behavioural, physiological and psychological changes. The streptozotocin model was used for the induction of diabetes. In diabetic rats, decreased bodyweight, High-density lipoprotein (HDL), reduced glutathione (GSH), Superoxide dismutase (SOD), Catalase (CAT) and increased level of Blood glucose, total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL), very-low-density lipoprotein (VLDL) and TBARs was observed which was normalized by 200 mg/kg and 500 mg/kg extract of the plant. Conclusion: It shows that the ethanolic extract of SI showed significant antioxidant and antidiabetic activity directing it as a better therapeutic regimen in the treatment of diabetes and associated complications.