Psoriasis is a heterogeneous skin disease with many clinical presentations in patients with different medical backgrounds. Medical specialties such as rheumatology, pathology, and cardiology focus lately on the systemic inflammation nature of the psoriatic disease. From the Dermatologist's point of view, the revolution of therapeutic spectrum in many autoimmune skin diseases, as well as the progression noted in physiopathological mechanism, the skin comorbidities became an important issue regarding therapeutic choice.