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Systems biology is an emerging discipline that combines high-content, multiplexed measurements with informatic and computational modeling methods to better understand biological function at various scales. Here we present a detailed review of the methods used to create computational models and conduct simulations of immune function, We provide descriptions of the key data gathering techniques employed to generate the quantitative and qualitative data required for such modeling and simulationdoi:10.1146/annurev-immunol-030409-101317 pmid:21219182 pmcid:PMC3164774 fatcat:my2czdrjajd5ldhrm52k2fzd5a