AB0255 Does menopause affect disease activity of rheumatoid arthritis(RA)? an analysis from the ninja cohort in 2016

K. Nagahata, S. Tsuzuki, S. Hattori, K. Yomono, S. Suzuki, S. Takenouchi, R. Yokochi, N. Hagino, T. Matsui, S. Tohma
2018 Rheumatoid arthritis – prognosis, predictors and outcome   unpublished
those patients loosing DAS28-ESR remission over time: 58 patients lost DAS-ESR remission at least once during the 4 follow-up visits. Surprisingly, 24% (3 months), 36% (6 months), 24% (9 months) and 28% (12 months) of the patients still fulfilled the Boolean remission criteria. The only plausible reason for failing DAS28-ESR remission but staying in ACR/EULAR remission is an isolated elevation of the ESR, not accompanied by increased signs and symptoms of disease. Indeed all patients loosing
more » ... patients loosing DAS28-ESR remission but staying in ACR/EULAR Boolean remission had an elevated ESR equal or higher than 15 mm. However, if DAS28 scores were calculated by C-reactive protein in the same patients, they all fulfilled remission criteria. Conclusions: DAS28-ESR remission can be missed even if a patient fulfils the more stringent ACR/EULAR Boolean remission criteria. The reason for this remarkable constellation is an elevated erythrocyte sedimentation rate without any clinical symptoms. Hence, isolated elevations of erythrocyte sedimentation rate should be seen critical. These data show the limitations of individual instruments to assess remission in RA and show that interpretations of the erythrocyte sedimentation rate need to be done in the clinical context
doi:10.1136/annrheumdis-2018-eular.5516 fatcat:7f4wa735t5agdpsq77whs62sdi