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Colon-specific immune microenvironment regulates cancer progression versus rejection
Immunotherapies have achieved clinical benefit in many types of cancer but remain limited to a subset of patients in colorectal cancer (CRC). Resistance to immunotherapy can be attributed in part to tissue-specific factors constraining antitumor immunity. Thus, a better understanding of how the colon microenvironment shapes the immune response to CRC is needed to identify mechanisms of resistance to immunotherapies and guide the development of novel therapeutics. Methods: In an orthotopic mousedoi:10.1101/2020.01.02.892711 fatcat:4kuf7nqcvzdlfowjw7u6qlhl64