A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2019; you can also visit the original URL.
The file type is application/pdf
.
Integrated computational and Drosophila cancer model platform captures previously unappreciated chemicals perturbing a kinase network
[article]
2018
bioRxiv
pre-print
Drosophila provides an inexpensive and quantitative platform for measuring whole animal drug response. A complementary approach is virtual screening, where chemical libraries can be efficiently screened against protein target(s). Here, we present a unique discovery platform integrating structure-based modeling with Drosophila biology and organic synthesis. We demonstrate this platform by developing chemicals targeting a Drosophila model of Medullary Thyroid Cancer (MTC) with disease-promoting
doi:10.1101/344192
fatcat:ltcrro7jsjcf5j726e7goqoqqq