Correlation of Numerical Aberrations of Chromosomes X and 11 and Poor Prognosis in Squamous Cell Carcinomas of the Head and Neck

Xin Xie, Ole Petter F. Clausen, Morten Boysen
2006 Archives of Otolaryngology - Head and Neck Surgery  
Objective: To investigate the prognostic significance of chromosomal aberrations of chromosomes X and 11 in relation to disease-specific survival in head and neck squamous cell carcinoma. Setting: University hospital. Design: A 10-year retrospective clinical study. Information about clinical findings, treatment, and follow-up has been recorded prospectively. Patients: By means of the fluorescence in situ hybridization technique with centromeric probes for chromosomes X and 11, we analyzed 40
more » ... , we analyzed 40 randomly selected patients before treatment for T1 to T4 head and neck squamous cell carcinoma. Numerical aberrations were scored and evaluated in frozen sections. Main Outcome Measures: The significance of prognostic parameters was tested by the log-rank and Kaplan-Meier methods for the univariate analysis. The Cox proportional hazards regression model was used for multivariate analysis.
doi:10.1001/archotol.132.5.511 pmid:16702567 fatcat:bfuj5glurbgrhebzynvz2tifea