Alternative Splicing: New Insights from Global Analyses

Benjamin J. Blencowe
2006 Cell  
Recent analyses of sequence and microarray data have suggested that alternative splicing plays a major role in the generation of proteomic and functional diversity in metazoan organisms. Efforts are now being directed at establishing the full repertoire of functionally relevant transcript variants generated by alternative splicing, the specific roles of such variants in normal and disease physiology, and how alternative splicing is coordinated on a global level to achieve cell-and
more » ... c functions. Recent progress in these areas is summarized in this review.
doi:10.1016/j.cell.2006.06.023 pmid:16839875 fatcat:wx2ma3g3qnbn7bpxbldvkrr4oi