Attention, Concentration and Planning Ability Improvement in Response to Depression Treatment during Acute Psychiatric Hospitalization

Luba Leontieva, Sergey Golovko, Aadhar Adhlakha, Lyuba Polinkovsky, Charles Harris, Donald A Cibula Thomas Schwartz, James L Megna
2017 Clinical Depression  
Cognitive symptoms are some of the most distressing for patients who are depressed. The goal was to investigate whether depressed patients' cognition changed depending on treatment with SSRIs (No-NOR) vs. Norepinephrine-enhancing medications (NOR) during an inpatient stay. Methods: This was an observational, naturalistic, pilot study that used a repeated measures design. 119 depressed inpatients, average age 39 years, 61% females, 77% Caucasian, 74% with mood disorders, 50% Cluster B
more » ... luster B traits/disorders and 32% psychoactive substance abuse disorders participated. The Trail Making Test (TMT), Hamilton Depression Rating Scale (HDRS), and Outcome Questionnaire-45(OQ-45) were used. Results: Revealed significant differences between admission and discharge in HDRS (MA=24, MD=9, t (98)=25.30, p<0.001), and OQ-45 (MA=105, MD=72, t (97)=12.91, p<0.001) scores. Mean time to complete the TMT-A at discharge for all NOR patients was 32.92 ± 22.47 seconds, and was significantly shorter than the comparable mean for the No-NOR group (39.10 ± 18.88 seconds, t=-2.33, p=0.022). Conclusion: Patients taking SNRIs, alone or in combination with benzodiazepines, Seroquel or TCAs (NOR), had significantly shorter completion times for the TMT-A test at discharge than did patients taking SSRIs, with or without benzodiazepines (No-NOR). This cognitive improvement developed independently of significant reductions in depressive symptomatology and interpersonal/social functioning impairment.
doi:10.4172/2572-0791.1000123 fatcat:lsoovf3lqvgwdp3jctpvjrkn5u