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Po-208 human zebrafish xenografts as therapy sensors for breast cancer
Poster Presentation: Tumour Biology
Material and methods A genetically engineered nanocarrier based on human ferritin heavy chain (HFt) able to incorporate and deliver drugs was developed. These nanoparticles contain a short motif sequence (MP) cleavable by matrix metalloproteases between the HFt subunit and a masking sequence rich in proline (P), alanine (A) and serine (S): HFt-MP-PASE40. A topoisomerase I inhibitor was loaded into these nanocarriers (HFt-MP-PASE-Topo). Cell viability of different pancreatic cancer cell linesdoi:10.1136/esmoopen-2018-eacr25.727 fatcat:mufvi4cam5e6zb5swpvg2nkxxe