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The roles of mechanical compression and chemical irritation in regulating spinal neuronal signaling in painful cervical nerve root injury
2013
Stapp Car Crash Journal
Both traumatic and slow-onset disc herniation can directly compress and/or chemically irritate cervical nerve roots, and both types of root injury elicit pain in animal models of radiculopathy. This study investigated the relative contributions of mechanical compression and chemical irritation of the nerve root to spinal regulation of neuronal activity using several outcomes. Modifications of two proteins known to regulate neurotransmission in the spinal cord, the neuropeptide calcitonin
pmid:24435733
fatcat:aan4cpg7erfz7kfvp7wg2d57lq