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In this study, in vitro (21 kinds of cell lines) and in vivo (four kinds of tumor-bearing mouse models) experiments were performed to determine the anticancer effect of doxycycline. This drug may elicit a strong inhibitory effect on cancer cells and improve the survival condition of mice. This study also preliminarily investigated the inhibitory effect of doxycycline on different kinds of tumor cells.doi:10.5430/jst.v6n1p103 fatcat:blgzo2oen5glpbz53cvptq2drq