Coordinated Conditional Simulation with SLINK and SUP of Many Markers Linked or Associated to a Trait in Large Pedigrees

Alejandro A. Schäffer, Mathieu Lemire, Jürg Ott, G. Mark Lathrop, Daniel E. Weeks
2011 Human Heredity  
to simulate a much larger number of markers on the same chromosome, linked and possibly associated with a trait locus. We have released new coordinated versions of SLINK (3.0; available from http://watson.hgen.pitt.edu) and SUP (v090804; available from http://mlemire.freeshell.org/software or http://watson.hgen.pitt.edu) that integrate the two software packages. Thereby, we have removed some of the previous limitations on the joint functionality of the programs, such as the number of founders
more » ... a pedigree. We review the history of SLINK and describe how SLINK and SUP are now coordinated to permit the simulation of large numbers of markers linked and possibly associated with a trait in large pedigrees.
doi:10.1159/000324177 pmid:21734403 pmcid:PMC3136384 fatcat:iql62ds73ze4vjye53cbiyr5jy