DEGREE OF ASSOCIATION BETWEEN FLUDEOXYGLUCOSE UPTAKE IN PALATINE TONSILS IN PET SCAN AND HISTOPATHOLOGIC EXAMINATION IN FOLLOW UP CASES OF NON-HODGKIN'S LYMPHOMA AND HODGKIN'S LYMPHOMA
English

Sanajeet K. Singh, Sameer Sameul, Devender K. Gupta, Ravi Roy, Rajeev Chugh, Sunil Goyal, Sandeep Dhaka, Kirti Sangwan
2019 Journal of Evolution of Medical and Dental Sciences  
BACKGROUND Lymphomas are heterogeneous group of malignancies that has distinct biological behaviour. FDG-PET is the investigation of choice used to stage and restage lymphoma patients. False-positive results are possible, because of infection, inflammation, hypermetabolic brown fat surrounding lymph nodes or reactive process producing strong 18F-FDG uptake. In these cases, and not uncommonly after chemotherapy, reactive enlargement of the lymph nodes, tonsils, and thymus gland can be detected.
more » ... d can be detected. METHODS Prospective study of 30 follow up patients who underwent chemotherapy for lymphoma showing FDG uptake with standardized uptake value max of 5.0 and above on PET scan in palatine tonsil. RESULTS In our study, we found that association between FDG uptake on PET scan and relapse on histopathological examination was not significant at p value of 0.084. CONCLUSIONS We found no significant relationship between increase in FDG uptake on PET scan and relapse, in palatine tonsils, in follow up cases of lymphoma, following histopathology results. HOW TO CITE THIS ARTICLE: Singh SK, Samuel S, Gupta DK, et al. Degree of association between fludeoxyglucose uptake in palatine tonsils in pet scan and histopathologic examination in follow up cases of non-Hodgkin's lymphoma and Hodgkin's lymphoma. BACKGROUND Lymphomas are heterogeneous group of malignancies that has distinct biological behaviour according to the subtype and the degree of differentiation. Lymphomas can be divided into two main groups: Hodgkin's (HL) and non-Hodgkin (NHL). The most common type is NHL which represents approximately 85% of all lymphomas. FDG-PET is the investigation of choice used to stage and restage HL and NHL. Staging HL and NHL with FDG-PET is directly dependent on many different factors including biological and technical aspects of the lymphoma. One of the most important factors is the histology. Normally, the most common subtypes of HL and the most aggressive NHL, such as diffuse large B cell lymphoma (DLBCL), show high levels of cell proliferation that reflect in a higher aerobic glycolysis rate 'Financial or Other Competing Interest': None.
doi:10.14260/jemds/2019/289 fatcat:kx2qcvz52jhk7ozribxwvy3d44