The long-term response to treatment with calcium channel blockers in a patient with idiopathic pulmonary arterial hypertension

P. Solik, P. Lesny, M. Luknar, I. Varga, E. Goncalvesova
2013 Bratislava Medical Journal  
Pulmonary arterial hypertension (PAH) is a disease characterised by a gradual increase in resistance of pulmonary circulation leading to right ventricular failure and death. In only 10 % of cases, there is a response to acute vasoreactivity testing with a signifi cant reduction in mean pulmonary artery pressure (PAP), while in this group of patients, less than one half of cases benefi t from long-term treatment with calcium channel blockers (CCB). This paper describes a case report of a young
more » ... tient with dyspnoea and suspicion of pulmonary hypertension who was referred to a specialised centre. The complex evaluation of her clinical state led to confi rmed diagnosis of idiopathic pulmonary arterial hypertension (IPAH). Because there was a positive response to vasoreactivity testing, the treatment for IPAH was initiated with a high dose of CCB. This treatment markedly improved her clinical state as well as echocardiographic and hemodynamic fi ndings. In this study, the authors present a diagnostic algorithm in pulmonary hypertension and emphasise the role of CCB in treatment of PAH in carefully selected patients (Tab. 1, Fig. 5, Ref. 7) . Full Text in PDF
doi:10.4149/bll_2013_058 fatcat:x6abc4wcjrbrzphgf47nup3zkm