Background. Cardiovascular disease (CVD) contributes to be one of the leading causes of death in the population worldwide. Carotid arterial stiffness and local hemodynamics are associated with the occurrence and development of CVD. Therefore, understanding the alterations of human carotid arterial stiffness and hemodynamics is of great clinical value in the prevention and treatment of CVD. Objective. In this study, we aimed to investigate the acute effect of high-intensity interval cycling

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... ) on carotid arterial stiffness and hemodynamics in sedentary. Methods. Thirty volunteered healthy sedentary males were enrolled in this study. HIIC intervention (3 sets, 20 s per set) was performed individually. A color Doppler ultrasound was applied to detect the images of the arterial inner diameters and center-line velocity waveforms at the right common carotid artery at different time points (at rest, 3 min, 15 min, and 30 min) after HIIC. Synchronously, electronic manometer was used to measure the systolic and diastolic pressures at the left brachial artery. Results. Arterial stiffness increased and arterial diameter decreased significantly after acute HIIC. The variation in stiffness persisted for 30 min, at least 15 min longer than the change in diameter. At 3 min after exercise, maximum and mean wall shear stresses (WSS) increased and minimum WSS was also higher than the resting value. At 30 min after exercise, WSS returned to the baseline, but oscillating shear index was still higher than the resting value. Conclusions. In summary, arterial stiffness and hemodynamics changed significantly not only at 3 min but also at 30 min after acute HIIC.