Few existing studies on the global incidence, prevalence, and burden of disease from psoriasis are of high quality, making reliable data and comparisons difficult to find. We analyzed global psoriasis trends from 1990 to 2017 in 195 countries worldwide through the Global Burden of Disease Study (GBD) database, including age-standardized prevalence rates, percent change in age-standardized prevalence rates, age and sex patterns, and psoriasis burden using disability adjusted life years. The

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... pecific prevalence rate in 2017 demonstrated a left skewed distribution with a peak between 60 and 70 years of age, and a roughly equal male:female ratio across all ages. Psoriasis burden was greatest in high income and high sociodemographic index countries. A positive linear relationship between psoriasis prevalence and comorbidities is seen with cardiovascular disease (R = .67), mental health (R = .63), type 2 diabetes mellitus (.55), stroke (R = .51), non-Hodgkin's lymphoma (R = .84), Hodgkin's lymphoma (R = .77), non-melanoma skin cancer (R = .68), and inflammatory bowel disease (R = .55) across all countries in 2017. There is increasing prevalence, burden, and associated comorbidities of psoriasis on a global scale, and the need for support to reduce this important global health disparity.