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Inhibition of GMP synthesis extends yeast replicative lifespan
Aging, the time-dependent accumulation of molecular damage, is the primary limiting factor of human lifespan. Slowing down damage accumulation or its prevention therefore represents a promising therapeutic paradigm to combat aging-related disease and death. While several chemical compounds extend lifespan in model organisms, their mechanism of action is often unknown, reducing their therapeutic potential. Using a systematic approach, here we show that inhibition of GMP synthesis is a noveldoi:10.1101/629428 fatcat:ofn4tm7qrvadncpztcgkf3pgwm