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Silencing epigenetic writer DOT1L attenuates intimal hyperplasia
Objective: Histone methyltransferases are emerging targets for epigenetic therapy. DOT1L (disruptor of telomeric silencing 1-like) is the H3K79 methylation writer. We investigated its role in the development of intimal hyperplasia (IH). Approach and Results: IH was induced via balloon angioplasty in rat carotid arteries. DOT1L and its catalytic products H3K79me2 and H3K79me3 (immunostaining) increased by 4.69 ±0.34, 2.38 ±0.052, and 3.07 ±0.27 fold, respectively, in injured (versus uninjured)doi:10.1101/730572 fatcat:va3hzlnm7vd5fmxyb4vzwqqwxy