NT - pro - BNP IN DIABETES MELLITUS
Journal of Evolution of Medical and Dental Sciences
BACKGROUND: Brain natriuretic peptide (BNP) is a peptide hormone that is synthesized largely by the heart in the form of pre-pro-BNP which is cleaved to pro-BNP, and then proteolyzed to BNP and NT-pro-BNP. ANP, BNP and NT-pro-BNP are sensitive diagnostic markers for heart failure. NT-pro-BNP being more sensitive is preferable to BNP and ANP for the detection of heart failure. Several studies have shown that NT-pro-BNP level is higher in diabetics. We have here tried to study the same dividing
... the same dividing the diabetic population duration-wise. MATERIALS AND METHODS: Patients with uncomplicated diabetes mellitus aged below 50 years were selected irrespective of sex. Patients without diabetes mellitus were taken as controls (Group A). Others viz., Group B consists of DM patients suffering from diabetes mellitus for a period <1 year, Group C consists of DM patients suffering for a period >2 year but <6 years and Group D comprises patients of uncomplicated DM for a period >10 years. NT-pro-BNP values in plasma are determined by AQT 90 FLEX NT-pro BNP Assay. Blood samples are collected with EDTA as anti-coagulant and plasma is separated. A Roche Modular Analytics E170 immuno assay analyser was used. RESULTS: The results show that the plasma NT-pro-BNP becomes progressively higher in diabetic patients with increased duration of diabetes when compared to the normal healthy controls. The difference in plasma NT-pro-BNP levels of Groups A and D showed a high degree of statistical significance but the difference was not statistically significant in case of Group B and Group C. CONCLUSION: It was found that uncomplicated DM patients of short and moderate duration had greater plasma NT-pro-BNP levels than the age matched non-diabetic healthy group though the difference is not significant. However the levels of NT-pro-BNP in patients of Group D were even higher than Group B and C (Gr A vs. Gr D: p<0.005). Diabetic patients can be periodically checked for NT-pro BNP to detect early onset Diabetic cardiomyopathy or other cardiac disorders as suggested by high NT-pro-BNP levels.