vs 54% (97/181) respectively (p=0.59). The commonest comorbidity in this study cohort were respiratory conditions, followed by neurological and oncological conditions. The proportion of children who tested SARS-CoV-2 positive was similar between the clinically vulnerable and non-vulnerable groups. (13.5% [7/52] vs 13.9% [22/158]; p=0.85). Conclusions In our study cohort, there was no single symptom or cluster of symptoms predictive of a positive SARS-CoV-2 test. The only association that we

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... d with SARS-CoV-2 positivity was belonging to a BAME group. Having comorbidities or being clinically vulnerable did not increase the likelihood of a children being SARS-CoV-2 positive. As presenting symptoms are not accurately predictive of SARS-CoV-2 detection, our study suggests that cohorting children based on clinical symptoms alone, could potentially increase the risk of transmission of infection within healthcare facilities. Until rapid and accurate point-of-care testing is widely available, a shift of emphasis from symptom-based cohorting towards measures such as physical distancing and use of face coverings, will enable better protection.