Delta oscillations are a robust biomarker of dopamine depletion severity and motor dysfunction in awake mice [article]

Timothy C. Whalen, Amanda M Willard, Jonathan E Rubin, Aryn H Gittis
2020 bioRxiv   pre-print
Delta oscillations (0.5-4 Hz) are a robust but often overlooked feature of basal ganglia pathophysiology in Parkinson's disease and their relationship to parkinsonian akinesia has not been investigated. Here, we establish a novel approach to detect spike oscillations embedded in noise to provide the first study of delta oscillations in awake, dopamine depleted mice. We find that approximately half of neurons in the substantia nigra reticulata exhibit delta oscillations in dopamine depletion and
more » ... amine depletion and that these oscillations are a strong indicator of dopamine loss and akinesia, outperforming measures such as changes in firing rate, irregularity, bursting and synchrony. We further establish that these oscillations are caused by the loss of D2 receptor activation and do not require motor cortex, contrary to previous findings in anesthetized animals. These results give insight into how dopamine loss leads to dysfunction and suggest a reappraisal of delta oscillations as a biomarker in Parkinson's disease.
doi:10.1101/2020.02.09.941161 fatcat:vjbqb3mqtvcsxjdzhyhlsip7iy