Losers of Primary Cilia Gain the Benefit of Survival

Gladiola Goranci-Buzhala, Elke Gabriel, Aruljothi Mariappan, Jay Gopalakrishnan
2017 Cancer Discovery  
In this issue, Zhao and colleagues demonstrate that loss of primary cilia in medulloblastoma cells confers resistance to the Smoothened (SMO) inhibitor sonidegib. When treated with sonidegib, medulloblastoma cells lost their cilia and gained resistance. Surprisingly, loss of cilia is associated with recurrent mutations in ciliogenesis genes that are eventually able to drive drug resistance. These fi ndings uncover a previously unknown mechanism of cancer cells in gaining a "persister-like"
more » ... against anticancer agents at the expense of losing primary cilia. Cancer Discov; 7(12); 1374-5.
doi:10.1158/2159-8290.cd-17-1085 pmid:29208776 fatcat:7wjjztduwjgi3mj33s6fj7qiwi