Research and Reviews: Research Journal of Biology PDDS: Innovative Technological Approach in Drug Delivery

Sunil Panuganti
unpublished
Commentary The non-invasive and rational delivery systems abstract to overcome the onerous barriers which piling up the clinical benefit of therapeutic outputs[1] seeing the accurate demands of regulatory accountability [2]. The novel drug delivery system (Pulsatile drug delivery system) conceivably optimizes dosage, intensify therapeutic agent accomplishment and lessen the systemic side effects are enforced in conventional drugs, based on their financial benefits along with recent classes of
more » ... recent classes of biopharmaceutical [3] and pharmaceutical products [4]. The recent technologies transformed by different levels to attain more productive pharmacological assessment [5]. Since decades, the scenario of drug delivery has been enterprising endeavor of the Pharma companies that incorporate technologically a rapid development and peculiar approaches in assessing medical needs [6]. Employment of computer in drug discovery has noted a revolutionary change in practice of drug designing. At the beginning, drug designing process was time-taking, arduous and expensive, and has high possibility of failure [7]. But, today the drug discovery process has become decisive, authentic and economical due to scope of large amount of genomic and proteomic data, application of tools for modeling, ligand designing, pharmacophore mapping, protein-ligand simulation, molecular descriptors and toxicity prediction [8,9]. Nanotechnology is the current area of research which draws the attention of numerous investigators and researchers around the scientific world which offers confident podiums for gaining therapeutic advancements in clinical fields [10]. The nano-technological studies on drug delivery systems are increasing periodically [11] in the aspects like route of administrations of the drugs and different pathological circumstances [12]. Considering available reports and results on the nanotechnology, it is already proved to minimize several barriers in topics of drug delivery by overcoming specific drug targeting, bioavailability [13], adverse/unwanted effects and stability of the active ingredients [14]. The other concerning subjects include drug efficacy [15], quality and toxicity of the active ingredients within the lipophilic drugs [16]. Pulsatile drug delivery system (PDDS) has attracted lot of interest of the researchers due to their betterment over the conventional drugs [17]. The PDDS delivers the drug at the appropriate time in applicable time and amount which is advantageous over the conventional drugs and commercial yielding. PDDS are designed conceding to the circadian rhythm of the body, and the drug is released rapidly and completely as a pulse after a lag time by following sigmoid release profile characterized by a time period [18]. Drugs showing first-pass effect and drugs which require nocturnal dosing with chronopharmacological behavior this delivery system are beneficial [19]. Classification of PDDS is done into three categories [20] as timed controlled release system Stimuli induced release system and externally regulated release system. In time controlled delivery system pulsatile release is retrieved after precise time in order to minimize the cardiac rhythms. It consist of two peripherals, one is immediate release type and second is pulsed release type. The stimuli induced release system follows the drug release after stimulation by any other biological factor (temperature, etc.). Depending upon the stimuli this release system further classified into temperature
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