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Blood loss during total knee replacement (TKR) remains a significant concern. In this study, 114 patients underwent TKR, and were divided into two groups based on whether they received a new generation fibrin sealant intra-operatively, or a local infiltration containing adrenaline. Groups were then compared for mean calculated total blood volume (TBV) loss, transfusion rates, and knee range of movement. Mean TBV loss was similar between groups: fibrin sealant mean was 705 ml ( 281 to 1744),doi:10.1302/0301-620x.95b11.32904 pmid:24187372 fatcat:njfqcud2ibhdho2j5nf6zvwmcm