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Iodine-122-labeled amphetamine derivative with potential for PET brain blood-flow studies
1985
Journal of Nuclear Medicine
The positron emitter 122I (t1/2 3.6 min) was collected from a xenon-122/iodine-122 (122Xe/122I) generator and incorporated into an amphetamine analog, 2,4-dimethoxy-N,N-dimethyl-5-[122I]iodophenylisopropylamine (5-[122I]-2,4-DNNA). The remote synthesis was achieved in 3 min with a 50% radioincorporation yield and a product radiopurity of greater than 98%. 5-[122I]-2,4-DNNA was injected into a beagle dog and a brain section imaged with positron emission tomography (PET). The uptake and retention
pmid:3877152
fatcat:ud2cttq2gjgifgaqkau5koru44