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The aim of this research was to produce novel antitumor fluoroquinolones from antibacterial analogs by introduction of a heterocyclic ring as a bioisostere of the C-3 carboxylic acid group. To this end, two series of eleven s-triazole derivatives bearing functionalized side chains of Schiff bases and Schiff-Mannich bases were designed and synthesized. Structures were characterized by elemental analysis and spectral data after which in vitro antitumor activity against L1210, CHO and HL60 celldoi:10.1016/j.apsb.2011.11.003 fatcat:szspavb6rvb6lhux33zvvfpqmm