INVITRO STUDIES ON INHIBITION OF Α-AMYLASE AND α-GLUCOSIDASE BY LEAVES AND ROOT ETHANOLIC EXTRACT OF CLERODENDRUM INERME

Gaertn Thirumal, P Muthusamy
Pharma Science Monitor   unpublished
Diabetes mellitus is a clinical condition described by hyperglycemia in which a raised measure of glucose circulates in the blood plasma. α-amylase and α-glucosidase are key enzymes involved in carbohydrates breakdown and intestinal absorption, respectively. The present study expects to screen α-amylase and α-glucosidase inhibitors from ethanolic concentrates of leaves and roots of Clerodendrum inerme Gaertn at different concentrations with a specific end goal to minimize the side effects and
more » ... side effects and toxicity of the inhibitors like Acarbose. Restraint of these enzymes proteins prevents blood glucose level increment after a carbohydrate diet carbohydrate diet and can be a critical technique in the administration of non-insulin-dependent diabetes mellitus [NIDDM]. The IC50 value of ethanolic leaf extract required to inhibit α-amylase and α-glucosidase was found to be 65.64 and 54.00 µg/mL respectively. The IC50 value of ethanolic root extract required to inhibit α-amylase and α-glucosidase was found to be 76.98 and 46.70 µg/mL respectively. The results of the work therefore clearly indicate the potential of these extracts to manage hyperglycemia.
fatcat:yu6xirun4jajnpyg3b4jha4xi4